Wednesday, 13 April 2016


Paracetamol interactions with other medicines have been classified into three following categories:

1. Major Drug Interaction:
It is suggested that it may be harmful if paracetamol taken with other medicines. It is highly clinically significant. Avoid this combination. Risk is very high

2. Moderate Drug Interaction: It is moderately clinically significant. Studies suggest that you should usually avoid this combination. Risk is moderate. 

3. Minor Drug Interaction: It is minimally clinically significant. Risk is very low if paracetamol taken with medicines.

Following 12 drugs have been found to have Major Drug Interaction with Paracetamol: 

1. Alcohol (Ethanol)
2. Alcohol 5% in Dextrose 5%
3. Alcohol and Dextrose Injection USP
4. Amyl Nitrate / Sodium Nitrate
5. Leflunomide
6. Teriflunomide
7. Epinephrine
8. Cyanide Antidote Kit
9. Prelocaine
10. Lidocaine Topical
11. Mipomersen
12. Lomitapide

Some Anti-Convulsant drugs having interaction with Paracetamol like:

1. Amobarbital
2. Butalbital
3. Pantobarbitol
4. Phenobarbital
5. Secobarbital
6. Carbamazepine

With these Anti-Convulsant drugs paracetamol will increase risk of liver damage.

Non Narcotic Analgesic like Diflunisal having interaction with paracetamol. it increase level of paracetamol in plasma by 50%.

Isoniazid, A typical Anti-Tuberculosis drug having drug interaction with paracetamol.

Warfarin, A blood thinner interact with paracetamol and increase risk of uncontrollable bleeding. 

Certain cholesterol lowering agent like Cholestyramine decrease the pharmacological effect of paracetamol. 


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